Oprah Winfrey is over the two decades of “blame” and “shame” surrounding her weight, revealing to People magazine this week that her use of weight-loss medication has been “a second shot for me to live a more vital and vibrant life.” Winfrey said the decision came after a lengthy recovery from knee surgery that began in 2021. “The fact that there's a medically approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for. I’m absolutely done with the shaming from other people and particularly myself,” Winfrey told People. “Obesity is a disease. It’s not about willpower—it’s about the brain.”